How Did the Updated 2019 European Society of Cardiology/European Atherosclerosis Society Risk Categorization for Patients with Diabetes Affect the Risk Perception and Lipid Goals? A Simulated Analysis of Real-life Data from EPHESUS Study

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dc.authorid0000-0002-3920-1382
dc.authorwosidA-6945-2019
dc.contributor.authorBaşaran, Özcan
dc.contributor.authorDoğan, Volkan
dc.contributor.authorMert, Kadir Uğur
dc.contributor.authorBekar, Lütfü
dc.contributor.authorKalçık, Macit
dc.contributor.author...
dc.date.accessioned2024-01-25T08:19:14Z
dc.date.available2024-01-25T08:19:14Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: The recent 2019 European Society of Cardiology/European Atherosclerosis Society practice guidelines introduced a new risk categorization for patients with diabetes. We aimed to compare the implications of the 2016 and 2019 European Society of Cardiology/European Atherosclerosis Society guidelines with regard to the lipid-lowering treatment use, low-density lipoprotein cholesterol goal attainment rates, and the estimated proportion of patients who would be at goal in an ideal setting. Methods: Patients with diabetes were classified into 4 risk categories according to 2019 European Society of Cardiology/European Atherosclerosis Society dyslipidemia guidelines from the database of EPHESUS (cross-sectional, observational, countrywide registry of cardiology outpatient clinics) study. The use of lipid-lowering treatment and low-density lipoprotein cholesterol goal attainment rates were then compared according to previous and new guidelines. Results: This analysis included a total of 873 diabetic adults. Half of the study population (53.8%) were on lipid-lowering treatment and almost one-fifth (19.1%) were on highintensity statins. While low-density lipoprotein cholesterol goal was achieved in 19.5% and 7.5% of patients, 87.4% and 69.6% would be on target if their lipid-lowering treatment was intensified according to 2016 and 2019 European Society of Cardiology/European Atherosclerosis Society lipid guidelines, respectively. The new target <55 mg/dL could only be achieved in 2.2% and 8.1% of very high-risk primary prevention and secondary prevention patients, respectively. Conclusion: The control of dyslipidemia was extremely poor among patients with diabetes. The use of lipid-lowering treatment was not at the desired level, and high-intensity lipid-lowering treatment use was even lower. Our simulation model showed that the highdose statin plus ezetimibe therapy would improve goal attainment; however, it would not be possible to get goals with this treatment in more than one-third of the patients.
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dc.description.provenanceMade available in DSpace on 2024-01-25T08:19:14Z (GMT). No. of bitstreams: 1 macit-kalcik2023.pdf: 2623837 bytes, checksum: 6d2bd718fe44245e571d134f3062d78e (MD5) Previous issue date: 2023en
dc.identifier.citationBaşaran, Ö., Doğan, V., Mert, K. U., Özlek, B., Özlek, E., Çelik, O., ... & Kayıkçıoğlu, M. (2023). How Did the Updated 2019 European Society of Cardiology/European Atherosclerosis Society Risk Categorization for Patients with Diabetes Affect the Risk Perception and Lipid Goals? A Simulated Analysis of Real-life Data from EPHESUS Study. Anatolian Journal of Cardiology, 27(2), 78.
dc.identifier.doi10.14744/AnatolJCardiol.2022.2012
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.pmid36747449
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/11491/8737
dc.identifier.wosWOS:000956673700007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorBekar, Lütfü
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherKARE PUBL
dc.relation.ispartofTHE ANATOLIAN JOURNAL OF CARDIOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes mellitusen_US
dc.subjectDyslipidemiaen_US
dc.subjectAtherosclerosisen_US
dc.subjectLipid guidelinesen_US
dc.subjectLow-density lipoprotein cholesterolen_US
dc.subjectCardiovascular risken_US
dc.titleHow Did the Updated 2019 European Society of Cardiology/European Atherosclerosis Society Risk Categorization for Patients with Diabetes Affect the Risk Perception and Lipid Goals? A Simulated Analysis of Real-life Data from EPHESUS Study
dc.typeArticle

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