Fragmented QRS complexes are a marker of myocardial fibrosis in hypertensive heart disease

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dc.contributor.authorBekar, Lütfü
dc.contributor.authorKatar, Muzaffer
dc.contributor.authorYetim, Mücahit
dc.contributor.authorÇelik, Oğuzhan
dc.contributor.authorKilci, Hakan
dc.contributor.authorÖnalan, Orhan
dc.date.accessioned2019-05-13T08:58:39Z
dc.date.available2019-05-13T08:58:39Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: Carboxy-terminal propeptide of type 1 procollagen (PICP) is a marker of extracellular collagen synthesis. Fragmented QRS (fQRS) on a 12-lead electrocardiogram (ECG) has been demonstrated as a marker of myocardial fibrosis. The present objective was to investigate the association between serum PICP concentration and presence of fQRS on ECG in hypertensive patients. Methods: Consecutive patients with previously or newly diagnosed hypertension were included. fQRS was defined as the presence of additional R-wave (R?), or notching of R- or Swaves, or the presence of fragmentation in 2 contiguous ECG leads. Serum PICP levels were measured by ELISA method. Results: The study group consisted of 90 hypertensive patients (74% females, with a mean age of 54.7±8.5 years). Of these patients, 47 (52.2%) had fQRS on ECG. Age (p=0.121) and gender distribution (p=0.625) were similar in patients with or without fQRS. Receiver operating characteristic curve analysis yielded a strong predictive ability of PICP levels for the presence of fQRS (area under the curve: 0.850; 95% CI: 0.772-0.929; p<0.0001). In multivariate logistic regression analysis, PICP levels were strongly and independently associated with the presence of fQRS (OR: 1.938; 95% CI: 1.398-2.688). Conclusion: Serum PICP level is a strong and independent predictor of fQRS. Discriminative performance of serum PICP levels for the presence of fQRS is high. The present results are the first to demonstrate that fQRS may indicate myocardial fibrosis in patients with hypertension. © 2016 Turkish Society of Cardiology.
dc.identifier.citationBekar, L., Katar, M., Yetim, M., Çelik, O., Kilci, H., Önalan, O. (2016). Fragmented QRS complexes are a marker of myocardial fibrosis in hypertensive heart disease. Türk Kardiyoloji Derneği Arşivi, 44(7), 554-560.
dc.identifier.doi10.5543/tkda.2016.55256
dc.identifier.endpage560en_US
dc.identifier.issn1016-5169
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage554en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2016.55256
dc.identifier.urihttps://hdl.handle.net/11491/1176
dc.identifier.volume44en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Society of Cardiology
dc.relation.ispartofTürk Kardiyoloji Derneği Arşivi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFragmented QRS Complexesen_US
dc.subjectHypertensionen_US
dc.subjectMycardial Fibrosisen_US
dc.subjectProcollagenen_US
dc.titleFragmented QRS complexes are a marker of myocardial fibrosis in hypertensive heart disease
dc.typeArticle

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