Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks of gestation in a case-control study of 33 pregnant women diagnosed with PE and in 43 normotensive pregnant women without proteinuria. The Mann-Whitney U test and Spearman's correlation were used for statistical analysis. Results: The median serum HO1 level was found to be significantly higher in the PE group [76.7 ng/ml (23.4-445.7)] than control group [55.9 ng/ml (3.7-354.3)] (p = 0.006). Positive correlation was found between HO1 levels with presence of PE (r = 0.316, p = 0.005). There was no significant difference in NDRG1 values between the two groups (p = 0.226). Conclusions: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women. © Informa Healthcare USA, Inc.
Açıklama
Anahtar Kelimeler
Heme Oxygenase 1, N-Myc Downstream-Regulated Gene 1, Oxidative Stress, Preeclampsia
Kaynak
Hypertension in Pregnancy
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
33
Sayı
4
Künye
Erdemli, H. K., Yıldırımlar, P., Alper, T. Y., Kocabaş, R., Salis, O., Bedir, A. (2014). Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia. Hypertension in Pregnancy, 33(4), 488-497.
