Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia

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dc.contributor.authorErdemli, Hacı Kemal
dc.contributor.authorYıldırımlar, Pınar
dc.contributor.authorAlper, Tayfun Yaşar
dc.contributor.authorKocabaş, Ramazan
dc.contributor.authorSalış, Oman
dc.contributor.authorBedir, Abdülkerim
dc.date.accessioned2019-05-13T08:59:01Z
dc.date.available2019-05-13T08:59:01Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks of gestation in a case-control study of 33 pregnant women diagnosed with PE and in 43 normotensive pregnant women without proteinuria. The Mann-Whitney U test and Spearman's correlation were used for statistical analysis. Results: The median serum HO1 level was found to be significantly higher in the PE group [76.7 ng/ml (23.4-445.7)] than control group [55.9 ng/ml (3.7-354.3)] (p = 0.006). Positive correlation was found between HO1 levels with presence of PE (r = 0.316, p = 0.005). There was no significant difference in NDRG1 values between the two groups (p = 0.226). Conclusions: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women. © Informa Healthcare USA, Inc.
dc.identifier.citationErdemli, H. K., Yıldırımlar, P., Alper, T. Y., Kocabaş, R., Salis, O., Bedir, A. (2014). Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia. Hypertension in Pregnancy, 33(4), 488-497.
dc.identifier.doi10.3109/10641955.2014.946613
dc.identifier.endpage497en_US
dc.identifier.issn1064-1955
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage488en_US
dc.identifier.urihttps://doi.org/10.3109/10641955.2014.946613
dc.identifier.urihttps://hdl.handle.net/11491/1240
dc.identifier.volume33en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofHypertension in Pregnancy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHeme Oxygenase 1en_US
dc.subjectN-Myc Downstream-Regulated Gene 1en_US
dc.subjectOxidative Stressen_US
dc.subjectPreeclampsiaen_US
dc.titleIncreased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia
dc.typeArticle

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