The possible role of CCR5?32 mutation in Crimean-Congo hemorrhagic fever infection
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Crimean-Congo hemorrhagic fever infection (CCHF) is a viral zoonosis. The pathogenesis of this disease has not been established so far, however, cytokines account for its progression and outcome. The aim of the present study is to investigate the association between chemokine receptor 5 (CCR5) gene ?32 mutation and pathogenity, severity, and mortality of CCHF. This case-control study included 133 CCHF patients diagnosed by detection of CCHV RNA positivity and 97 healthy control subjects. CCR5 gene ?32 mutation analyzed by polymerase chain reaction (PCR) method. The results were compared by using SPSS 16.0 and WINPEPI software's. The genotype distribution and allele frequency of the CCR5?32 were statistically different between the patients and the control group (P = 0.017; OR: 4.98 95% CI = 1.65-14.99 and P = 0.019; OR:4.76 95%CI = 1.30-17.50, respectively). CCR5/CCR5 (W/W) genotype and W allele of CCR5 gene were more common in patient group than in controls. There was no significant difference in severe and mild cases with regard to genotype distribution and allele distribution of CCR?32 mutation (P >0.05). These results suggest that the CCR5 gene and its product might play a role in the pathogenesis of CCHF disease. Future studies will help us to uncover the exact role of CCR5 in the pathogenesis and prognosis of CCHF and to treat the disease. © 2017 Wiley Periodicals, Inc.
Açıklama
Anahtar Kelimeler
Chemokine Receptor 5 Gene, Crimean-Congo Hemorrhagic Fever, Δ32 Mutation
Kaynak
Journal of Medical Virology
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
89
Sayı
10
Künye
Rustemoglu, A., Ekinci, D., Nursal, A. F., Barut, S., Duygu, F., & Günal, Ö. (2017). The possible role of CCR5? 32 mutation in Crimean-Congo hemorrhagic fever infection.
