The possible role of CCR5?32 mutation in Crimean-Congo hemorrhagic fever infection

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dc.authorid0000-0002-1354-4598
dc.authorid0000-0001-7639-1122
dc.contributor.authorRüstemoğlu, Aydın
dc.contributor.authorEkinci, Duygu
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorBarut, Şener
dc.contributor.authorDuygu, Fazilet
dc.contributor.authorGünal, Özgür
dc.date.accessioned2019-05-10T09:39:32Z
dc.date.available2019-05-10T09:39:32Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractCrimean-Congo hemorrhagic fever infection (CCHF) is a viral zoonosis. The pathogenesis of this disease has not been established so far, however, cytokines account for its progression and outcome. The aim of the present study is to investigate the association between chemokine receptor 5 (CCR5) gene ?32 mutation and pathogenity, severity, and mortality of CCHF. This case-control study included 133 CCHF patients diagnosed by detection of CCHV RNA positivity and 97 healthy control subjects. CCR5 gene ?32 mutation analyzed by polymerase chain reaction (PCR) method. The results were compared by using SPSS 16.0 and WINPEPI software's. The genotype distribution and allele frequency of the CCR5?32 were statistically different between the patients and the control group (P = 0.017; OR: 4.98 95% CI = 1.65-14.99 and P = 0.019; OR:4.76 95%CI = 1.30-17.50, respectively). CCR5/CCR5 (W/W) genotype and W allele of CCR5 gene were more common in patient group than in controls. There was no significant difference in severe and mild cases with regard to genotype distribution and allele distribution of CCR?32 mutation (P >0.05). These results suggest that the CCR5 gene and its product might play a role in the pathogenesis of CCHF disease. Future studies will help us to uncover the exact role of CCR5 in the pathogenesis and prognosis of CCHF and to treat the disease. © 2017 Wiley Periodicals, Inc.
dc.identifier.citationRustemoglu, A., Ekinci, D., Nursal, A. F., Barut, S., Duygu, F., & Günal, Ö. (2017). The possible role of CCR5? 32 mutation in Crimean-Congo hemorrhagic fever infection.
dc.identifier.doi10.1002/jmv.24865
dc.identifier.endpage1719en_US
dc.identifier.issn0146-6615
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1714en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.24865
dc.identifier.urihttps://hdl.handle.net/11491/722
dc.identifier.volume89en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChemokine Receptor 5 Geneen_US
dc.subjectCrimean-Congo Hemorrhagic Feveren_US
dc.subjectΔ32 Mutationen_US
dc.titleThe possible role of CCR5?32 mutation in Crimean-Congo hemorrhagic fever infection
dc.typeArticle

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