Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Associacao Brasileira de Divulgacao Cientifica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Recurrent aphthous ulcer (RAU) is an inflammatory condition of the oral mucosa characterized by painful, well-circumscribed, single or multiple round or ovoid ulcerations. The exact etiologic factor(s) of these ulcerations are not yet understood. The objective of this study was to evaluate inflammatory processes and free radical metabolism of 25 patients with RAUs compared to 25 healthy controls. The levels of malondialdehyde (MDA) and glutathione (GSH) were determined by high-performance liquid chromatography. Tumor necrosis factor-alpha (TNF-?), interleukin-2 (IL-2), IL-10, and IL-12 were determined by ELISA. Nitric oxide (NO), myeloperoxidase (MPO), total antioxidant status (TAS), and total oxidant status (TOS) levels were measured spectroscopically in serum. The levels of MDA, GSH, TNF-?, IL-2, IL-12, MPO, and TOS, and oxidative stress index (OSI) were higher, and the levels of NO, IL-10, and TAS were lower in patients with RAU than in controls. Statistical analysis showed that GSH, TNF-?, IL-2, IL-10, and OSI differed significantly in patients with RAU compared to controls. These parameters have important roles in oxidant/antioxidant defense.
Açıklama
Anahtar Kelimeler
Cytokines, Oxidative Stress, Recurrent Aphthous Ulcer
Kaynak
Brazilian Journal of Medical and Biological Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
47
Sayı
5
Künye
Avcı, E., Zafersoy Akarslan, Z., Erten, H., Coşkun-Cevher, Ş. (2014). Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers. Brazilian Journal of Medical and Biological Research, 47(5), 355-360.
