Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers

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dc.authorid0000-0003-1046-8208
dc.contributor.authorAvcı, Emre
dc.contributor.authorZafersoy Akarslan, Zühre
dc.contributor.authorErten, Hülya
dc.contributor.authorCoşkun Cevher, Şule
dc.date.accessioned2019-05-13T09:08:06Z
dc.date.available2019-05-13T09:08:06Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractRecurrent aphthous ulcer (RAU) is an inflammatory condition of the oral mucosa characterized by painful, well-circumscribed, single or multiple round or ovoid ulcerations. The exact etiologic factor(s) of these ulcerations are not yet understood. The objective of this study was to evaluate inflammatory processes and free radical metabolism of 25 patients with RAUs compared to 25 healthy controls. The levels of malondialdehyde (MDA) and glutathione (GSH) were determined by high-performance liquid chromatography. Tumor necrosis factor-alpha (TNF-?), interleukin-2 (IL-2), IL-10, and IL-12 were determined by ELISA. Nitric oxide (NO), myeloperoxidase (MPO), total antioxidant status (TAS), and total oxidant status (TOS) levels were measured spectroscopically in serum. The levels of MDA, GSH, TNF-?, IL-2, IL-12, MPO, and TOS, and oxidative stress index (OSI) were higher, and the levels of NO, IL-10, and TAS were lower in patients with RAU than in controls. Statistical analysis showed that GSH, TNF-?, IL-2, IL-10, and OSI differed significantly in patients with RAU compared to controls. These parameters have important roles in oxidant/antioxidant defense.
dc.identifier.citationAvcı, E., Zafersoy Akarslan, Z., Erten, H., Coşkun-Cevher, Ş. (2014). Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers. Brazilian Journal of Medical and Biological Research, 47(5), 355-360.
dc.identifier.doi10.1590/1414-431X20143714
dc.identifier.endpage360en_US
dc.identifier.issn0100-879X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.1590/1414-431X20143714
dc.identifier.urihttps://hdl.handle.net/11491/1936
dc.identifier.volume47en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssociacao Brasileira de Divulgacao Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytokinesen_US
dc.subjectOxidative Stressen_US
dc.subjectRecurrent Aphthous Ulceren_US
dc.titleOxidative stress and cellular immunity in patients with recurrent aphthous ulcers
dc.typeArticle

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