Investigation of the relationship between ACAN geneVNTR polymorphism and Alzheimer’s disease inTurkish population

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dc.contributor.authorKeskin, Tuğba
dc.contributor.authorAvşar, Orçun
dc.contributor.authorEliaçık, Sinan
dc.contributor.authorUysal Tan, Funda
dc.date.accessioned2024-08-02T11:07:42Z
dc.date.available2024-08-02T11:07:42Z
dc.date.issued2024en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAlzheimer’s disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. In this study, it was aimed to reveal the relationship between Alzheimer’s disease and the variable number tandem repeat (VNTR) polymorphism in the aggrecan (ACAN) gene. Thus, it is thought that it will contribute to enlightenment about disease by contributing to the pathophysiology of Alzheimer’s disease. A total of 203 people, including 102 patients diagnosed with Alzheimer’s and 101 healthy individuals, were included in the study. Deoxyribonucleic acid (DNA) extraction was performed from the blood samples taken. The variable number tandem repeat (VNTR) polymorphism of the ACAN gene was determined using the Polymerase Chain Reaction (PCR) method. In our study, the 30?R, 31?R and 33?R alleles were the most repetitive alleles in patients and controls. 30?R, 31?R and shorter alleles were more common in patients than in the control group and were found to be statistically significant (p?=?0.042). According to our results, 30?R and 31?R alleles of the VNTR polymorphism in the ACAN gene may be associated with Alzheimer’s disease. In addition, having less than 30 repeat alleles increases the risk of the disease by 2,202 times. Our study is the first to investigate the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease. Further studies are needed to definitively relate it.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-08-02T11:06:50Z No. of bitstreams: 0en
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dc.description.provenanceMade available in DSpace on 2024-08-02T11:07:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2024en
dc.identifier.citationKeskin, T., Avsar, O., Eliacik, S., & Uysal Tan, F. (2024). Investigation of the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease in Turkish population. Nucleosides, Nucleotides & Nucleic Acids, 1-10.
dc.identifier.doi10.1080/15257770.2024.2311783
dc.identifier.issn1525-7770
dc.identifier.issn1532-2335
dc.identifier.pmid38340307
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1080/15257770.2024.2311783
dc.identifier.urihttps://hdl.handle.net/11491/9049
dc.identifier.wosWOS:001159358700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskin, Tuğba
dc.institutionauthorAvşar, Orçun
dc.institutionauthorEliaçık, Sinan
dc.institutionauthorUysal Tan, Funda
dc.language.isoen
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlzheimer’s diseaseen_US
dc.subjectAggrecanen_US
dc.subjectACAN geneen_US
dc.subjectPolymorphismen_US
dc.titleInvestigation of the relationship between ACAN geneVNTR polymorphism and Alzheimer’s disease inTurkish population
dc.typeArticle

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