Relation of serum ADMA, Apelin-13 and LOX-1 levels with inflammatory and echocardiographic parameters in hemodialysis patients

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dc.authorid0000-0002-3922-4517
dc.contributor.authorDoğan, İbrahim
dc.contributor.authorDoğan, Tolga
dc.contributor.authorYetim, Mücahit
dc.contributor.authorKayadibi, Hüseyin
dc.contributor.authorYılmaz, Mehmet Bertan
dc.contributor.authorEser, Barış
dc.contributor.authorKalçık, Macit
dc.contributor.authorKaravelioğlu, Yusuf
dc.date.accessioned2019-05-13T09:07:05Z
dc.date.available2019-05-13T09:07:05Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractCardiovascular diseases are the leading causes of mortality in patients with chronic kidney disease. Nitric oxide has a critical role in both endothelial dysfunction and the atherosclerosis process. We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients. The study comprised a total of 120 patients (53 females and 67 males) receiving hemodialysis three times a week for at least 6 months and an age-gender matched control group (55 females and 58 males). Serum ADMA, LOX-1, and Apelin-13 levels were measured using the ELISA technique. Echocardiography, 24-h blood pressure monitoring by the Holter and carotid artery intima-media thickness (CIMT) measurement was performed on all of the included subjects. The associations between serum ADMA, LOX-1, and Apelin-13 levels with CIMT, echocardiographic parameters [left ventricular mass (LVM) and left ventricular mass index (LVMI)], and inflammatory markers [high sensitive C-reactive protein (hsCRP) and neutrophil lymphocyte ratio (NLR)] were evaluated by correlation analysis. Serum ADMA, Apelin-13, and LOX-1 levels were significantly higher in the hemodialysis group than the controls (P < 0.001, P < 0.001, and P < 0.001, respectively). CIMT, hsCRP, and NLR levels were also significantly higher in the hemodialysis group (P < 0.05, P < 0.001, P < 0.001, respectively). Significant correlations were observed among the serum ADMA, Apelin-13, and LOX-1 levels. Moreover, notably positive correlations were found between these three biochemical markers and LVM, LVMI, hsCRP, and CIMT. Serum ADMA, Apelin-13, and LOX-1 levels can be indicators not only for the inflammatory process but also for the pathogenesis of cardiovascular diseases in hemodialysis patients. © 2017 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy
dc.identifier.citationDoğan, İ., Doğan, T., Yetim, M., Kayadibi, H., Yılmaz, M. B., Eser, B., Kalçık, M., Karavelioglu, Y. (2018). Relation of serum ADMA, Apelin-13 and LOX-1 levels with inflammatory and echocardiographic parameters in hemodialysis patients. Therapeutic Apheresis and Dialysis, 22(2), 109-117.
dc.identifier.doi10.1111/1744-9987.12613
dc.identifier.endpage117en_US
dc.identifier.issn1744-9979
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.1111/1744-9987.12613
dc.identifier.urihttps://hdl.handle.net/11491/1721
dc.identifier.volume22en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofTherapeutic Apheresis and Dialysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApelin-13en_US
dc.subjectAsymmetric Dimethyl Arginineen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectHemodialysisen_US
dc.subjectLOX-1en_US
dc.titleRelation of serum ADMA, Apelin-13 and LOX-1 levels with inflammatory and echocardiographic parameters in hemodialysis patients
dc.typeArticle

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