Assessing the relationship between antipsychotic drug use and prolidase enzyme activity and oxidative stress in schizophrenia patients: a case-control study

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dc.contributor.authorYazla Asaf, Ece
dc.contributor.authorÇetin, İhsan
dc.contributor.authorKayadibi, Hüseyin
dc.date.accessioned2024-01-30T07:48:13Z
dc.date.available2024-01-30T07:48:13Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground The relationship between proline, its association with oxidative stress, and its connection to schizophrenia is a subject that has not been sufficiently investigated. Objective The aim of this study is to evaluate the possible effects of atypical and combined (typical and atypical) antipsychotic use on serum prolidase enzyme activity (SPEA) and serum oxidative stress parameters, and to assess the relationship between SPEA and oxidative stress in patients with schizophrenia. Methods A total of 57 patients with schizophrenia, of which 34 were using atypical (AAPG) and 23 were using combined (typical and atypical) (CAPG) antipsychotic therapy, and 28 healthy volunteers (control group) were included in this case-control study. Results SPEA levels of AAPG and CAPG were significantly lower than that of control group (P = 0.003). The oxidative stress index (OSI) value of AAPG was significantly higher than the other two groups (P = 0.001). SPEA (<1860 U/l) and OSI (?0.54) could discriminate schizophrenia patients with antipsychotic therapy from control groups (P = 0.001 and P = 0.007, respectively). Lower SPEA levels were associated with antipsychotic use (P = 0.007). Conclusion The SPEA values of patients with schizophrenia on antipsychotics were significantly lower compared to controls. OSI values were significantly higher in atypical antipsychotic recipients compared to those on combined antipsychotics and healthy controls.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-01-30T07:48:02Z No. of bitstreams: 0en
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dc.description.provenanceMade available in DSpace on 2024-01-30T07:48:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationYazla, E., Cetin, I., & Kayadibi, H. (2023). Assessing the relationship between antipsychotic drug use and prolidase enzyme activity and oxidative stress in schizophrenia patients: a case-control study. International Clinical Psychopharmacology, 38(6), 394-401.
dc.identifier.doi10.1097/YIC.0000000000000491
dc.identifier.issn0268-1315
dc.identifier.issn1473-5857
dc.identifier.pmid37490605
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11491/8756
dc.identifier.wosWOS:001076924400005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYazla Asaf, Ece
dc.institutionauthorÇetin, İhsan
dc.language.isoen
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofInternational Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntipsychoticen_US
dc.subjectOxidative stress indexen_US
dc.subjectProlidaseen_US
dc.subjectSchizophreniaen_US
dc.subjectTotal oxidant/antioxidant statusen_US
dc.titleAssessing the relationship between antipsychotic drug use and prolidase enzyme activity and oxidative stress in schizophrenia patients: a case-control study
dc.typeArticle

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